MBE, honokiol, and magnolol were all effective against killing bacteria responsible for halitosis and formation of dental caries (ie, Streptococcus mutans).11, 12, 13 The MIC ranged from 8 to 31 mcg/mL for magnolol, honokiol, and MBE against Porphyromonas gingivalis, Fusobacterium nucleatum, and S. mutans. However, MBE + xylitol reduced mutans streptococci concentrations (P=0.04) and bleeding upon probing (P=0.04) significantly better than xylitol without MBE.71 (Campus, 2011), Magnolol reduced swelling and inflammation in edema induced by carrageenan, compound 48/80, polymyxin B, and reversed passive Arthus reaction in mice.15 When compared with dexamethasone, magnolol did not increase glycogen levels in the liver. Other ingredients in the smoothie can help mask the bark’s taste in case it doesn’t appeal to you. The extract also has anti-oxidant and anti-bacterial properties, which helps to neutralise free radicals and decelerate the aging process. People use the bark and flower buds to make medicine. You also agree that the data may also be transferred to third countries outside the European Economic Area without an adequate level of data protection (esp. After 12 weeks, the addition of MBE provided a significant improvement in insomnia, irritability, and libido at 4, 8 and 12 weeks.70, A double-blind, randomized, controlled interventional trial (n=120) in Italy investigated the effect of MBE on factors related to dental caries, such as cariogenic bacteria (especially mutans streptococci), fermentable carbohydrates intake, plaque acidity, and saliva flow. However, this same protective process contributes to the aging process. You should talk with your health care provider for complete information about the risks and benefits of using this product. Name: magnolia grandiflora l. bark extract: CAS Number: 85085-47-8: ECHA EC Number: 285-376-6: Category: antimicrobial, antioxidants agents . Documentation on the materials and extracts for several studies is also limited. See all the important information about this ingredient. Magnolol and honokiol exhibited central depressant effects by producing sedation, ataxia, muscle relaxation, and a loss of the righting reflex in young chicks.19 The compound 4-O-methylhonokiol (4-O-MH) promoted neurite outgrowth in a concentration-dependent manner in cultured embryonic neuronal cells. There are certain things to be kept in mind. The dosage of the extract should be between 250 to 500 mg per day. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. An animal study documented that honokiol and magnolol blocked calcium-dependent uterine oscillatory contractions in rat uterus.5. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) The compound also increased expression of neurotrophins, which are believed to promote neurite outgrowth.20 An ethanol extract of M. officinalis and 4-O-MH suppressed beta amyloid peptide (eg, Aβ1–42)–induced memory impairment in mice, perhaps by inhibiting neuronal cell death, and increased reactive oxygen species expression.21 The compound 4-O-MH may also inhibit activation of the mitogen-activated protein kinase (MAP kinase) pathway, which is important in neuronal cell death.22 An ethanol extract of M. officinalis and 4-O-MH improved memory impairment induced by scopolamine in a dose-dependent manner.23, In an agar dilution study, honokiol and magnolol inhibited (minimum inhibitory concentration [MIC] = 25 mcg/mL) the growth of periodontal pathogens Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Micrococcus luteus, and Bacillus subtilis11 and were less potent than tetracycline. Magnolol is able to cross the blood brain barrier, as documented by pharmacokinetic studies in rats.32, Honokiol alone inhibited the growth of human lung cancer A549 in lung carcinoma models, and when combined with cisplatin, enhanced antitumor efficacy by increasing apoptosis and inhibition of angiogenesis.33 Honokiol inhibited several human breast cancer cell lines, as well as drug-resistant breast cancer cell lines. Products Ingredients Decode INCI Login Register. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Celebrated as a herbal remedy for treating the stagnation of qi (energy), for digestive disorders, anxiety and allergic diseases, Magnolia bark extract can also help to prevent the loss of skin elasticity and reduce reddening of the skin. Cutipure CLR … Magnolia bark extract is an ancient herbal remedy from Ancient Chinese medicine. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age. Nature Magnolia Bark Extract 98% Magnolol Powder . The study summarized above was the only study included that evaluated magnolia bark extract.73. Maybe not. Magnolia, from these three species, was formerly official. Both delivery forms were well tolerated with no reported problems.74, 75 A 2017 systematic review of chewing gum and its impact of halitosis parameters (ie, volatile sulfur compounds, organoleptic scores) in adults evaluated 10 trials that exhibited high heterogeneity; no study was at low risk of bias in all analysis items. Drug-herb interactions are documented, and caution is advisable in patients self-medicating with MBE. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. The mechanism involved inhibition of cell proliferation, induced cell cycle arrest, and apoptosis. Both compounds also enhanced vitamin D3 and all-trans-retinoic acid induced HL-60 leukemic cell differentiation.31, Magnolol suppressed growth of cultured human U373 malignant glioblastoma cells by inhibiting DNA synthesis and activating apoptosis. Drug-herb interactions are documented, and caution is advisable in patients self-medicating with MBE. You can decline or withdraw your consent at any time here. A human skin irritation test in 30 healthy patients demonstrated no adverse effects from topical application of the phenolic compounds. Honokiol and magnolol inhibited the growth of acne-causing bacteria Cutibacterium acnes and Cutibacterium granulosum.14 Both phenolic compounds also reduced inflammation by inhibiting the secretion of interleukin-8 and tumor necrosis factor alpha (TNF-alpha) induced by P. acnes. Documentation on the materials and extracts for several studies is also limited. Another plant extract combination containing M. officinalis, KIOM-79, inhibited xylose-induced lens opacity.43 KIOM-79 also protected human lens epithelial-B3 cells from the toxic effects of high glucose levels by inhibiting transforming growth factor beta, which is involved in the pathophysiology of ocular damage. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. This information is not specific medical advice and does not replace information you receive from your health care provider. Magnolol's antioxidant activity appears to also play a role in preventing atherosclerotic vascular disease.55, 56 Antiplatelet activity relaxes vascular smooth muscle by releasing endothelium-derived relaxing factor and inhibiting calcium influx through voltage-gated calcium channels.57, Honokiol induced apoptosis and inhibited angiogenesis via the Bcl-2 and caspase-3 pathway in ovarian tumor cells.24 Honokiol increased apoptotic DNA fragmentation in cultured human prostate cancer cells irrespective of their androgen responsiveness or p53 status and inhibited growth of an androgen-independent p53 mutant cell line xenograft in mice without causing weight loss or any other adverse reactions.25 Magnolol inhibited growth and induced apoptosis, and G1- and G2/M phase cell cycle arrest in human urinary bladder cancer 5637 cells by activating extracellular signaling.26 Magnolol inhibited growth of human malignant melanoma A375-S2 cells by both the death receptor pathway and the mitochondrial pathway.27 Honokiol reduced cell survival and inhibited growth in human chondrosarcoma cells, a malignant primary bone tumor.28 The anticancer activity involves mitochondria dysfunction and induced cell death mediated by increased endoplasmic reticulum stress, eventually resulting in apoptosis. Magnolia Bark Extract/cortex Magnolia Officinalis , Find Complete Details about Magnolia Bark Extract/cortex Magnolia Officinalis,Magnolia Bark Extract,Magnolia Extract,Magnolia Officinalis from Herbal Extract Supplier or Manufacturer-Shaanxi Yuantai Biological Technology Co., Ltd. Most literature sources are from Japanese and Chinese foreign-language publications, clinical studies are on the efficacy of magnolia bark extract (MBE) are limited. *All information provided on this page is general information only and is not necessarily applicable to products containing these ingredients. Granted Application number EP12190020.3A Other languages German (de) French (fr) MBE is commercially available in the United States and throughout Europe, as documented by Internet search engines. Dosage varies depending on the condition treated, with weight loss products containing MBE available mostly in powder form. A small, randomized, controlled study treated patients with one 60 mg tablet of MBE daily to help relieve menopausal symptoms.45, Avoid use during pregnancy and lactation because of limited clinical data. Dosing recommendations include taking a 300 mg capsule of Relora 2 to 3 times per day. Follow the directions for use. Some sources document case reports of progressive interstitial renal fibrosis in patients consuming an herbal blend containing M. officinalis. PhytoDefense CLR™ by CLR Berlin acts as an anti-inflammatory and anti-redness agent. Magnolia bark is a natural remedy sourced from the magnolia tree (Magnolia officinalis) that has been used for centuries in traditional Chinese medicine (TCM).It contains a compound called honokiol that mimics the function of estrogen in the body. The compound exists at the level of a few . Magnolia bark extract is one of the most potent anti-wrinkle ingredients tested so far at NIVEA. Honokiol and magnolol also reduced elevated corticosterone concentrations and normalized hypothalamic–pituitary–adrenal hyperactivity and reduced platelet adenylyl cyclase activity by upregulating the cyclic adenosine monophosphate pathway.36, Experimentally induced depression in mice was inhibited by magnolol and its metabolite hydroxydihydromagnolol.37 An ethanol extract of a traditional Chinese medicine containing M. officinalis exhibited antidepressant effects in mice similar to the effects of fluoxetine.38 In a stress-induced model in rats, the combination of honokiol, magnolol, and ginger oil exhibited antidepressant effects. Enrolled participants were adults at high risk of dental caries and were randomized to MBE (0.17%) + xylitol, xylitol, or a control group. NEW: NIVEA Q10 Power Range for Mature Skin, NIVEA Hyaluron Cellular Filler Elasticity. But does this mean anybody can take the extract? This solution was used for the efficacy and irritancy studies. This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. MAGNOLIA GRANDIFLORA BARK EXTRACT. Honokiol and magnolol inhibited excitatory amino acid-evoked cation signals and N-methyl-D-aspartate acid (NMDA)–induced seizures.63 Honokiol was more selective in blocking the NMDA receptor and demonstrated greater inhibition against NMDA-induced seizures. No adverse dermatologic effects were documented with topical application of magnolol and honokiol.14 In one small clinical trial, a patient dropped out because of a number of adverse reactions, including heartburn, shaking hands, perilabial numbness, sexual dysfunction, and thyroid dysfunction.46 A few cases of allergic contact dermatitis have been reported in 4 patients who presented with a variety of symptoms, including vesicular, edematous, pruritic, scaly, and/or erythematous lesions after applying cosmetic creams containing M. officinalis bark extract. Mint candies containing MBE 0.2% reduced oral bacteria by 99.9% within 5 minutes of treatment. This is only a brief summary of general information about this product. Always read the label. Modern science is now exposing the health benefits of magnolia bark supplements. et Wils. The effect of zinc acetate and magnolia bark extract added to chewing gum on volatile sulfur-containing compounds in the oral cavity. Honokiol also enhanced the proapoptotic activity of lapatinib or rapamycin in her-2 over-expressed or low-expressed breast cancer models.34, Honokiol-hydrogel reduced the number of pleural tumor foci and prolonged survival time in malignant pleural effusion–bearing mice when compared with controls. Glycine Soja (Soybean) Oil, Dicaprylyl Ether, Magnolia Grandiflora Bark Extract and Lauryl Alcohol. No dermatologic adverse effects were documented with topical application of magnolol and honokiol; however, several cases of allergic dermatitis have been documented in case reports. This product may be unsafe when used before surgery or other medical procedures. View abstract. Chemical Composition.—The various species of Magnolia probably have analogous composition. roots penetrating deep into the earth and branches extending out to the sky USA). Additive adverse reactions with antiplatelet medications may occur in patients also self-medicating with magnolol. Magnolol may interact with acetaminophen; one study documented reduced acetaminophen-induced liver damage in rats.6 Additive adverse reactions with antiplatelet medications may occur in patients also self-medicating with magnolol.57 MBE and honokiol may interact with benzodiazepines.8, 52 Magnolol may stimulate corticosterone secretion58 or increase steroid medication concentrations.65 MBE may cause excess sleepiness, vertigo, and dizziness in patients taking muscle relaxants. US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information: Magnolol also attenuated upregulation of renal transforming growth factor beta 1, which plays a key role in the pathogenesis of diabetic nephropathy, and reduced expression of extracellular matrix protein as type IV collagen.40 In mature adipocytes, magnolol improved insulin sensitivity by increasing basal and insulin stimulated glucose uptake through peroxisome proliferator-activated receptors.41 KIOM-4, a plant extract obtained from M. officinalis, protected pancreatic beta cells against streptozotocin-induced oxidative damage.42 KIOM-4 induced a rate-limiting enzyme through the extracellular regulated kinase pathway, which resulted in cytoprotection against diabetic conditions and increased insulin release from the pancreas. bark extract skin cellulite magnolia bark magnolia Prior art date 2011-11-02 Legal status (The legal status is an assumption and is not a legal conclusion. The hope is to not simply mask bad breath, as most strongly flavored mints and gums do, but to kill odor-causing bacteria. The magnolia extract and magnesium combination appeared to be effective in reducing psychoaffective and sleep disturbances from menopause.45 A small pilot study examined the effects on body weight from a dietary supplement containing extracts of M. officinalis and Phellodendron amurense in 28 premenopausal women. MBE and honokiol may interact with benzodiazepines. magnolia grandiflora bark extract Manufacturers Directory ☆ 3 million global importers and exporters ☆ magnolia grandiflora bark extract suppliers, manufacturers, wholesalers, magnolia grandiflora bark extract sellers, traders, exporters and distributors from China and around the world at EC21.com This information relates to an herbal, vitamin, mineral or other dietary supplement. Available for Android and iOS devices. Magnolia Grandiflora Extract Magnolol, US $ 10 - 13 / Kilogram, Herbal Extract, magnolia grandiflora, Powder.Source from Xian Tonking Biotech Co., Ltd. on Alibaba.com. With age, our immune system slowly becomes less effective and inflammation can increase. Normally, the body can handle free radicals, but if antioxidants are unavailable, or if too many free radicals have been produced they can damage our cells. Magnolol is an organic compound that is classified as lignan. In one small clinical trial, a patient dropped out because of a number of adverse reactions, including heartburn, shaking hands, perilabial numbness, sexual dysfunction, and thyroid dysfunction. Most literature sources are from Japanese and Chinese foreign-language publications, clinical studies are on the efficacy of magnolia bark extract (MBE) are limited. Health Concerns of the Ingredient: Overall Hazard . Dosage varies depending on the condition treated, with weight loss products containing MBE available mostly in powder form. Research shows compounds in magnolia bark extract may help guard against weight gain and decrease body fat. Avoid use if hypersensitivity exists for any of the components in MBE. Magnolia bark extract is found in supplements, tea, toothpaste, and topical oils and cream. 2011. The Best Anti-Wrinkle Treatment for Your Skincare Routine. Since chronic inflammation is generally believed to play an important role in skin aging, Mibelle Biochemistry has developed a water-dispersible active powder based on magnolia bark extract to protect against inflammation. Caries Res. Join the myNIVEA community to get access to personalised skin care tips and tricks, membership only offers, new product information and loads more! Found in 4 beauty products. Magnolia Grandiflora Price - Select 2020 high quality Magnolia Grandiflora Price products in best price from certified Chinese Magnolia Bark Extract Powder manufacturers, Magnolia Denudata suppliers, wholesalers and factory on Made-in-China.com MBE may also have antimicrobial activity against Helicobacter pylori.12, Chewing sugarless gum containing either MBE (0.17%) + xylitol or xylitol without MBE was shown to improve mutans streptococci levels and bleeding on probing significantly better than control. EINECs: 285-376-6. Participants were instructed to chew 1 or 2 pieces of gum for 5 minutes 3 times daily for 30 days (5 pieces/day); this regimen delivered 11.9 mg/day of magnolol and 2.2 g/day of honokiol. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. Honokiol Promotes relaxation and sense of calm, while magnolol has anti-inflammatory and antineoplastic effects. 2012;23(3):76-9. Cancer . Magnolia bark also appears to have potent antibacterial and anti-inflammatory effects. Last updated on Jul 2, 2020. It has been used in traditional Chinese medicine called houpu or hou po for hundreds of years, and it is recognized worldwide for its medicinal properties. It is possible that authorities may access the data without any legal remedy. Magnolia Grandiflora Bark Extract is organic component used in cosmetics. You can also add the extract to your breakfast smoothie. Cells and cell culture: THP-1 cells b were cultured in a medium containing 10% heat-inactivated fetal bovine serum, 100 U/mL of penicillin and Magnolol may interact with acetaminophen. In vitro and animal studies document potential efficacy as an antibacterial, anti-inflammatory, and anticancer agent, as well as for use with Alzheimer disease, depression, diabetes, and menopause. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. MBE is commercially available in the United States and throughout Europe. All patients’ hypersensitivity were validated with positive reactions to patch testing.72, 76, Dietary administration of MBE in rats at doses of up to 480 mg/kg in a 21-day study and 240 mg/kg in a 90-day study resulted in no clinically important toxicity.7 Some sources document the development of progressive interstitial renal fibrosis in patients consuming an herbal blend containing M. officinalis.66, 67 In vitro studies demonstrate no genotoxic effects from MBE in chromosomal aberration assays.68 One study documented that magnolol in liver graft preservation enhanced apoptotic events under cold preservation instead of preserving hepatocyte integrity.69. One small, randomized, controlled study treated patients with one 60 mg tablet of MBE daily to help relieve menopausal symptoms. Documentation on the materials and extracts for several studies is also limited. Select one or more newsletters to continue. Several strengths are available for Relora, a patented blend marketed as "a natural stress management supplement" that includes MBE. This information should not be used to decide whether or not to take this product. Eastern Asia and America and inflammatory activity increases preventative activity irritation test 30. Purposes in Traditional Chinese medicine Agent: [ ANTIOXIDANTS & REDOX SIGNALING study found that magnolia grandiflora bark extract and magnolol uterine... S taste in case it doesn ’ t appeal to you may occur in patients taking muscle relaxants United. Mg capsule of Relora 2 to 3 times per day extract may help guard against weight gain decrease... 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